治白癜风吃什么药 http://pf.39.net/bdfyy/qsnbdf/160304/4780765.htmlMetaboliceffects代谢的影响
Asdiscussedearlier,prebioticinterventionresultsintheelaborationofSCFAsthatcanacttoimprovebarrierfunctioninthegut,andprebioticinterventionwithGOShasbeenshowntoimprovebarrierfunctioninvivo.Impairedbarrierfunctioncanallowtranslocationofinflammatorymediatorssuchasbacteriallipopolysaccharide(LPS)fromthegutintothesystemiccirculation,whichhasbeentermedmetabolicendotoxaemiaandhasbeensuggestedtobeacausativefactorindiabetesandobesity,althoughtheevidenceforthisisfromstudiesinmice.
如前所述，益生元干预会导致可改善肠道屏障功能的短链脂肪酸的形成，而低聚半乳糖益生元干预已被证明可改善体内屏障功能。屏障功能受损可以允许易位等炎症介质的细菌脂多糖(LPS)肠道进入体循环,被称为代谢内毒素血症并被暗示在糖尿病和肥胖中是一个诱发因素,尽管这种证据仅来自对老鼠的研究。
Themetaboliceffectsofprebioticshavebeenthesubjectofseveralmeta-analysesandalthoughtheresultsamongstudiesvary,thegeneralconsensusisthatprebioticinterventionhasapositiveeffectonglucosehomeostasis,inflammationandbloodlipidprofileinhumans.AlthoughinterventionswithGOSandinulinhavebeenshowntoimproveinflammatorymarkersinindividualswithobesity,thesewererelativelyshort-termstudiesoverafewmonths,andtheeffectonmetabolichealthoveralongperiodofconsumptionisyettobeestablished.
益生元的代谢作用已成为多项荟萃分析的课题，尽管研究结果各不相同，但普遍的共识是益生元干预对人体葡萄糖稳态、炎症和血脂有积极的影响。虽然低聚半乳糖和菊粉干预已被证明可改善肥胖患者的炎症标志物，但这些研究时间相对较短，仅持续几个月，而且长期服用对代谢健康的影响还有待证实。
ThehypothesisunderlyingmuchresearchonprebioticsandbarrierfunctionandinflammationisthatfermentationproductssuchasSCFAprobablymediatethebeneficialeffectsthroughmechanismsdiscussedearlier.However,ithasbeenshownthat,atleastinvitro,GOScandirectlystimulatetheexpressionoftightjunctionproteinsinintestinalepithelialcelllinesanddecreasetransepithelialflux.However,giventhatGOSisfermentedinthegut,theextenttowhichsuchmechanismsactinvivoisunclearatpresent.Itispossiblethattheeffectofinulininimprovingglycaemicresponsecouldbeduetodirectinhibitionoftheintestinalisomaltase–sucraseenzyme
